Enhance MD vs SynergyRx: Which GLP-1 Provider Is Better?
By Iacob Pastina, Independent Researcher
Enhance MD beats SynergyRx overall, scoring 7.8/10 vs 7.6/10. SynergyRx is more affordable at $199/mo vs $212/mo. Choose Enhance MD for budget-conscious users interested in combination therapies. Choose SynergyRx for users who want predictable bundled pricing with 24/7 support.
A side-by-side comparison of Enhance MD and SynergyRx covering pricing, scores, medication types, insurance, and more to help you decide.
Enhance MD
#17 of 40Affordable telehealth provider offering both compounded and brand-name GLP-1 medications with combination therapy options.
Visit Enhance MDSynergyRx
#22 of 40Bundled GLP-1 program with predictable pricing and round-the-clock support access for peace of mind.
Visit SynergyRx| Feature | Enhance MD | SynergyRx |
|---|---|---|
| Our Score | 7.8/10 | 7.6/10 |
| Starting Price | $212/mo | $199/mo |
| Medication Type | Both | Both |
| Insurance Accepted | No | No |
| Best For | Budget-conscious users interested in combination therapies | Users who want predictable bundled pricing with 24/7 support access |
| Ranking | #17 | #22 |
Pros & Cons Compared
Enhance MD
Pros
- +$115/mo starting price with access to both brand-name and compounded — rare at this price point
- +Offers combination therapies (GLP-1 + B12, GLP-1 + NAD+) for patients wanting enhanced protocols
- +Quick asynchronous consultations — most patients approved within 24 hours without video calls
- +Flexible dosing: can start at lower doses than standard protocols for sensitive patients
Cons
- −Lighter clinical support than higher-priced platforms — check-ins are patient-initiated, not scheduled
- −No insurance billing and limited customer support hours (business days only, no weekends)
SynergyRx
Pros
- +Oral dissolving tablets for BOTH semaglutide AND tirzepatide — one of the few platforms with needle-free tirzepatide
- +Free expedited shipping included with all orders
- +24/7 support with unlimited messaging — no per-visit fees for follow-up questions or dose adjustments
- +Both compounded and brand-name options available (Ozempic, Wegovy, Mounjaro)
Cons
- −Casper, WY registration address and limited independent reviews raise legitimacy questions
- −Brand-name pricing ($499-947/mo) is very high compared to direct manufacturer programs like LillyDirect
- −Company history, founding date, and ownership structure are not publicly disclosed
Our Verdict
Enhance MD edges out SynergyRx with a score of 7.8/10 vs 7.6/10. If budget is your priority, SynergyRx starts at $199/mo compared to Enhance MD's $212/mo. Choose Enhance MD if you want: budget-conscious users interested in combination therapies. Choose SynergyRx if you want: users who want predictable bundled pricing with 24/7 support access.